Reported Resistance Case(s)

Species: aphis gossypii

Order	Family	Common Name(s)	Group	Host
homoptera	aphididae	melon and cotton aphid	AG	cotton, vegetables

Active Ingredient: Cycloxaprid

MOA: Nicotinic Acetylcholine receptor agonists / antagonists, Neonicotinoids
Group: NICO	CAS #:	Shaugnessy Code: 0

Resistance Case(s)

Case Id	Year of Report	Type of Resistance	Location	Reference
G23461	2025	Lab selected*	China-- Hubei-- Yichang	Dong, W., Shang, J., Guo, X., Wang, H., Zhu, J., Liang, P., & Shi, X. (2025). Transcription factor CREB/ATF regulates overexpression of CYP6CY14 conferring resistance to cycloxaprid in Aphis gossypii. International journal of biological macromolecules,, 303.
G22538	2022	Lab selected after field-evolved resistance**	China-- Hubei-- Yichang	Dong, W., Yang, H., Wang, C., Li, H., Shang, J., Chen, Z., Zhang, H., Liang, P., Gao, X., & Shi, X. (2022). Cross-Resistance and Fitness Costs of the cis-Nitromethylene Neonicotinoid Cycloxaprid Resistance in Melon Aphid, Aphis gossypii (Hemiptera: Aphididae). Journal of economic entomology, 115.
G21670	2022	Lab selected after field-evolved resistance**	China-- Hubei-- Yichang	Dong, W., H. Yang, C. Wang, H. Li, J. Shang, Z. Chen, H. Zhang, P. Liang, X. Gao, and X. Shi. (2022). Cross-Resistance and Fitness Costs of the cis-Nitromethylene Neonicotinoid Cycloxaprid Resistance in Melon Aphid, Aphis gossypii (Hemiptera: Aphididae). Journal of Economic Entomology, 115 1668-1675.

*The population was created solely by selection and/or genetic manipulation.
**The population was selected further in the laboratory after collection.