Reported Resistance Case(s)

Species: rhipicephalus microplus

Order	Family	Common Name(s)	Group	Host
acari	ixodidae	southern/tropical cattle tick	MED	cattle

Active Ingredient: ivermectin

MOA: Chloride channel activators, Avermectins, Milbemycins
Group: ABM	CAS #: 70288-86-7	Shaugnessy Code: 0

Resistance Case(s)

Case Id	Year of Report	Type of Resistance	Location	Reference
G16584	2014	Field Evolved Resistance	Brazil-- Minas Gerais-- Formiga	Zanetti Lopes, W. D., Cruz, B. C., Pires Teixeira, W. F., Felippelli, G., Maciel, W. G., Buzzulini, C., Costa Gomes, L. V., Favero, F., Soares, V. E., Bichuette, M. A., Pereira de Oliveira, G., and Jose da Costa, A. (2014). Efficacy of fipronil (1.0 mg/kg) against Rhipicephalus (Boophilus) microplus strains resistant to ivermectin (0.63 mg/kg). Preventive Veterinary Medicine, 115 88-93.
G16585	2014	Field Evolved Resistance	Brazil-- Minas Gerais-- Andradas	Zanetti Lopes, W. D., Cruz, B. C., Pires Teixeira, W. F., Felippelli, G., Maciel, W. G., Buzzulini, C., Costa Gomes, L. V., Favero, F., Soares, V. E., Bichuette, M. A., Pereira de Oliveira, G., and Jose da Costa, A. (2014). Efficacy of fipronil (1.0 mg/kg) against Rhipicephalus (Boophilus) microplus strains resistant to ivermectin (0.63 mg/kg). Preventive Veterinary Medicine, 115 88-93.
G16586	2014	Field Evolved Resistance	Brazil-- Sao Paulo-- Franca	Zanetti Lopes, W. D., Cruz, B. C., Pires Teixeira, W. F., Felippelli, G., Maciel, W. G., Buzzulini, C., Costa Gomes, L. V., Favero, F., Soares, V. E., Bichuette, M. A., Pereira de Oliveira, G., and Jose da Costa, A. (2014). Efficacy of fipronil (1.0 mg/kg) against Rhipicephalus (Boophilus) microplus strains resistant to ivermectin (0.63 mg/kg). Preventive Veterinary Medicine, 115 88-93.
G14808	2012	Field Evolved Resistance	Mexico-- Veracruz	Fernandez-Salas, A., Rodriguez-Vivas, R.I., Alonso-Diaz, M.A., and Basurto-Camberos, H. (2012). Ivermectin resistance status and factors associated in Rhipicephalus microplus (Acari: Ixodidae) populations from Veracruz, Mexico. Veterinary Parasitology, 190 210-215.
G14809	2012	Field Evolved Resistance	Mexico-- Veracruz	Fernandez-Salas, A., Rodriguez-Vivas, R.I., Alonso-Diaz, M.A., and Basurto-Camberos, H. (2012). Ivermectin resistance status and factors associated in Rhipicephalus microplus (Acari: Ixodidae) populations from Veracruz, Mexico. Veterinary Parasitology, 190 210-215.
G14810	2012	Field Evolved Resistance	Mexico-- Veracruz	Fernandez-Salas, A., Rodriguez-Vivas, R.I., Alonso-Diaz, M.A., and Basurto-Camberos, H. (2012). Ivermectin resistance status and factors associated in Rhipicephalus microplus (Acari: Ixodidae) populations from Veracruz, Mexico. Veterinary Parasitology, 190 210-215.
G14811	2012	Field Evolved Resistance	Mexico-- Veracruz	Fernandez-Salas, A., Rodriguez-Vivas, R.I., Alonso-Diaz, M.A., and Basurto-Camberos, H. (2012). Ivermectin resistance status and factors associated in Rhipicephalus microplus (Acari: Ixodidae) populations from Veracruz, Mexico. Veterinary Parasitology, 190 210-215.
G14812	2012	Field Evolved Resistance	Mexico-- Veracruz	Fernandez-Salas, A., Rodriguez-Vivas, R.I., Alonso-Diaz, M.A., and Basurto-Camberos, H. (2012). Ivermectin resistance status and factors associated in Rhipicephalus microplus (Acari: Ixodidae) populations from Veracruz, Mexico. Veterinary Parasitology, 190 210-215.
G14813	2012	Field Evolved Resistance	Mexico-- Veracruz	Fernandez-Salas, A., Rodriguez-Vivas, R.I., Alonso-Diaz, M.A., and Basurto-Camberos, H. (2012). Ivermectin resistance status and factors associated in Rhipicephalus microplus (Acari: Ixodidae) populations from Veracruz, Mexico. Veterinary Parasitology, 190 210-215.
G14814	2012	Field Evolved Resistance	Mexico-- Veracruz	Fernandez-Salas, A., Rodriguez-Vivas, R.I., Alonso-Diaz, M.A., and Basurto-Camberos, H. (2012). Ivermectin resistance status and factors associated in Rhipicephalus microplus (Acari: Ixodidae) populations from Veracruz, Mexico. Veterinary Parasitology, 190 210-215.
G14815	2012	Field Evolved Resistance	Mexico-- Veracruz	Fernandez-Salas, A., Rodriguez-Vivas, R.I., Alonso-Diaz, M.A., and Basurto-Camberos, H. (2012). Ivermectin resistance status and factors associated in Rhipicephalus microplus (Acari: Ixodidae) populations from Veracruz, Mexico. Veterinary Parasitology, 190 210-215.
G9614	2009	Field Evolved Resistance	Brazil-- Sao Paulo-- Piquete	Klafke, G.M., Albuquerque, T.A., Miller, R.J., Schumaker, T.T.S. (2009). Selection of an ivermectin-resistant strain of Rhipicephalus microplus (Acari: Ixodidae)in Brazil. Veterinary Parasitology.
G9615	2009	Field Evolved Resistance	Brazil-- Sao Paulo-- Piquete	Klafke, G.M., Albuquerque, T.A., Miller, R.J., Schumaker, T.T.S. (2009). Selection of an ivermectin-resistant strain of Rhipicephalus microplus (Acari: Ixodidae)in Brazil. Veterinary Parasitology.

*The population was created solely by selection and/or genetic manipulation.
**The population was selected further in the laboratory after collection.